FIG 4.

Spontaneous recovery following exposure to a sublethal dose of BoNT/A. (A) Groups of mice (n = 3) were injected i.m. with various doses of BoNT/A on day 0. The activity of the animals on each night was normalized to its average activity on the 4 nights preceding toxin exposure. Each point represents the average of the group activity. The toxin doses were 0.15 (circles), 0.3 (squares), and 0.6 (triangles) i.m. LD₅₀. (B) Average days to recovery in mice exposed to the respective doses of BoNT/A. Recovery was defined as return of mouse’s activity to its individual average nocturnal running distance prior to toxin exposure − 2 SDs.