FIG 5.
Determination of the time window for next-generation antibotulinum therapeutics in the sublethal model. Mice were exposed to 0.3 i.m. LD50 of BoNT/A on day 0 and treated with a body-weight-normalized human dose of antitoxin at different time points. (A) Normalized activity in relation to the averaged activity over the 4 days preceding BoNT exposure. The antitoxin treatment time points are as follows: immediate treatment (open squares), 24 h from intoxication (closed triangles), or 72 h (open circles) from intoxication (closed squares, untreated group). (B) Average times to recovery for the different groups.