TABLE 2.
Antiviral activity, cytotoxicity, and selectivity index profiles of compounds 22 and trans-14 against the laboratory strain DENV2 NGC, evaluated in five susceptible cell linesa
| Compound | Vero |
BHK |
Huh |
Jeg3 |
A549 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EC50 | CC50 | SI | EC50 | CC50 | SI | EC50 | CC50 | SI | EC50 | CC50 | SI | EC50 | CC50 | SI | |
| 22 | 2.8 ± 2.8 | >100 | >35.7 | 0.15 ± 0.08 | >100 | >667 | 0.4 ± 0.1 | >100 | >250 | 1.0 ± 0.4 | >100 | >100 | 0.03 ± 0.02 | >100 | >3,000 |
| trans-14 | 2.8 ±1.9 | >100 | >35.7 | 0.08 ± 0.04 | >100 | >1,250 | 0.1 ± 0.08 | >100 | >1,000 | 0.3 ± 0.1 | >100 | >330 | 0.04 ± 0.02 | >100 | >2,500 |
a
Data are averages ± SD of at least three independent experiments. EC50s, CC50s, and SIs for the compounds in Vero cells are from Table 1.