TABLE 4.
Combination | Result for strain |
||||
---|---|---|---|---|---|
DA02 | DA17 | DA19 | DA26 | DA42 | |
Ketoconazole + ciclopirox | Additive | ND | Indifferent | Additive | Additive |
Ketoconazole + amphotericin B | Additive | ND | Indifferent | Additive | Additive |
Ketoconazole + terbinafine | Synergy | ND | Additive | Synergy | Additive |
Ketoconazole + fluconazole | Additive | ND | Additive | ND | ND |
Ketoconazole + luliconazole | Synergy | Additive | Synergy | Synergy | Additive |
Itraconazole + ciclopirox | Synergy | ND | ND | Additive | Additive |
Itraconazole + amphotericin | Additive | ND | ND | Indifferent | Indifferent |
Itraconazole + luliconazole | Synergy | Synergy | Synergy | Synergy | Additive |
Itraconazole + terbinafine | Synergy | Synergy | Synergy | Synergy | ND |
Itraconazole + ketoconazole | Synergy | Synergy | Synergy | Synergy | Additive |
Itraconazole + fluconazole | Synergy | ND | ND | ND | ND |
Fluconazole + amphotericin | Additive | Additive | ND | ND | Additive |
Fluconazole + terbinafine | Synergy | Additive | ND | ND | Additive |
Fluconazole + luliconazole | Additive | Additive | ND | ND | Additive |
Fluconazole + ciclopirox | Additive | Synergy | ND | ND | Additive |
Fluconazole + ketoconazole | Additive | ND | ND | ND | Additive |
PGMC + luliconazole | Synergy | Synergy | Additive | Synergy | Synergy |
PGMC + itraconazole | Indifferent | Synergy | Synergy | Additive | Additive |
PGMC + ketoconazole | Additive | Additive | Additive | Synergy | Additive |
PGMC + ciclopirox | Additive | Synergy | Additive | Additive | Additive |
PGMC + terbinafine | Additive | Additive | Synergy | Additive | Additive |
PGMC + fluconazole | Additive | Synergy | Additive | Additive | Additive |
PGMC + amphotericin | ND | Additive | Additive | ND | ND |
Synergy, FIC index of ≤0.5; additive, FIC index of >0.5 to 1; indifferent, FIC index of >1 to 4; antagonistic, FIC index of >4. ND, not determined.