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. 2021 Jul 16;65(8):e00321-21. doi: 10.1128/AAC.00321-21

TABLE 4.

Isolate-wise results of the checkerboard analysisa

Combination Result for strain
DA02 DA17 DA19 DA26 DA42
Ketoconazole + ciclopirox Additive ND Indifferent Additive Additive
Ketoconazole + amphotericin B Additive ND Indifferent Additive Additive
Ketoconazole + terbinafine Synergy ND Additive Synergy Additive
Ketoconazole + fluconazole Additive ND Additive ND ND
Ketoconazole + luliconazole Synergy Additive Synergy Synergy Additive
Itraconazole + ciclopirox Synergy ND ND Additive Additive
Itraconazole + amphotericin Additive ND ND Indifferent Indifferent
Itraconazole + luliconazole Synergy Synergy Synergy Synergy Additive
Itraconazole + terbinafine Synergy Synergy Synergy Synergy ND
Itraconazole + ketoconazole Synergy Synergy Synergy Synergy Additive
Itraconazole + fluconazole Synergy ND ND ND ND
Fluconazole + amphotericin Additive Additive ND ND Additive
Fluconazole + terbinafine Synergy Additive ND ND Additive
Fluconazole + luliconazole Additive Additive ND ND Additive
Fluconazole + ciclopirox Additive Synergy ND ND Additive
Fluconazole + ketoconazole Additive ND ND ND Additive
PGMC + luliconazole Synergy Synergy Additive Synergy Synergy
PGMC + itraconazole Indifferent Synergy Synergy Additive Additive
PGMC + ketoconazole Additive Additive Additive Synergy Additive
PGMC + ciclopirox Additive Synergy Additive Additive Additive
PGMC + terbinafine Additive Additive Synergy Additive Additive
PGMC + fluconazole Additive Synergy Additive Additive Additive
PGMC + amphotericin ND Additive Additive ND ND
a

Synergy, FIC index of ≤0.5; additive, FIC index of >0.5 to 1; indifferent, FIC index of >1 to 4; antagonistic, FIC index of >4. ND, not determined.