TABLE 1.
Overview of changes in cell envelope characteristics following β-lactam treatment of DAP-R strains compared to untreated strains and adaptations favorable for DAP activity
| Parameter | Value for druga |
|||||
|---|---|---|---|---|---|---|
| NAF | MEM | LOX | CRO | CEC | FOX | |
| Phenotype | ||||||
| Surface charge | − | − | − | − | + | − |
| Membrane fluidity | NC | − | − | − | + | − |
| CL content, cultures | NC | + | + | NC | NC | NC |
| CL content, cells | NC | + | + | NC | NC | + |
| DAP binding | − | NC | NC | − | + | NC |
| Potential mechanism of DAP potentiation | Decreased surface charge | Decreased surface charge | Decreased surface charge | Decreased surface charge | Increased DAP binding | Decreased surface charge |
| Decreased membrane fluidity | Decreased membrane fluidity | Decreased membrane fluidity | Decreased membrane fluidity | |||
| Increased CL content | Increased CL content | |||||
a
+, increased; −, decreased; NC, no change.