FIG 2.

Partner β-lactam activity in combination with VNRX-5236 against strains of Enterobacterales expressing serine β-lactamases. All testing was conducted according to the CLSI broth microdilution method, with VNRX-5236 fixed at 4 μg/ml and partner β-lactam titrated (26). Clinical isolates tested included (A) 12 E. coli and 13 K. pneumoniae; (B) 19 K. pneumoniae, 1 E. coli, 3 E. cloacae, and 2 Klebsiella oxytoca; (C) 13 K. pneumoniae and 12 E. coli; (D) 7 E. coli, 7 K. pneumoniae, 6 Serratia marcescens, 3 Klebsiella aerogenes, 1 Citrobacter freundii, and 1 Proteus mirabilis.