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Time-kill assay of CTB/VNRX-5236 against strains of Enterbacterales with defined resistance mechanisms. Hexagon, growth control; square, CTB alone at 8 μg/ml; open circle, CTB at 2 μg/ml with VNRX-5236 fixed at 4 μg/ml; × inside a circle, CTB at 2 μg/ml with clavulanic acid fixed at 4 μg/ml; upside-down triangle, amoxicillin at 8 μg/ml with clavulanic acid at 4 μg/ml (a 2:1 ratio); triangle, tebipenem at 2 μg/ml; diamond, sulopenem at 2 μg/ml.
