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. 2021 Jul 16;65(8):e00552-21. doi: 10.1128/AAC.00552-21

TABLE 1.

VNRX-5236 50% inhibition concentrations against serine β-lactamasesa

Ambler class β-lactamase IC50 (μM) for:
VNRX-5236 Avibactam Tazobactam Clavulanic acid
A CTX-M-15 0.02 0.003 0.001 0.04
KPC-2 0.08 0.06 1.7 1.8
C P99AmpC 0.01 0.02 0.73 >100
CMY-2 0.01 0.007 0.41 >100
D OXA-1 0.07 0.04 0.43 0.12
OXA-48 0.32 0.55 3.5 14.3
a

Substrates were nitrocefin for P99AmpC, CMY-2, OXA-1, and OXA-48; cefotaxime for CTX-M-15 and SHV-5; and imipenem for KPC-2. IC50 values are reported as the mean from duplicate measurements.