TABLE 4.

Activity of CTB/VNRX-5236 and comparators against Enterobacterales expressing class A ESBLs, class A carbapenemases (KPC), class C cephalosporinases, and class D oxacillinases^a

Ambler class type	Antimicrobial agent	MIC range (μg/ml)	MIC50 (μg/ml)	MIC90 (μg/ml)
A-ESBLb	CTB	0.12 to ≥64	8	≥64
	CTB/VNRX-5236	0.03–1	0.12	0.25
	CTB/CLA	0.03 to ≥64	0.12	0.5
	AMC	8 to ≥64	16	32
	Sulopenem	0.03–1	0.12	0.5
	Tebipenem	≤0.016–0.12	0.03	0.06
A-KPCc	CTB	0.5 to ≥64	16	≥64
	CTB/VNRX-5236	0.06–1	0.12	1
	CTB/CLA	0.25 to ≥64	8	≥64
	AMC	32 to ≥256	≥64	≥256
	Sulopenem	4 to ≥64	32	≥64
	Tebipenem	8 to ≥64	≥64	≥64
Cd	CTB	2 to ≥64	16	≥64
	CTB/VNRX-5236	0.03–2	0.12	1
	CTB/CLA	0.06 to ≥64	2	≥64
	AMC	8 to ≥256	32	≥256
	Sulopenem	0.03–8	0.06	2
	Tebipenem	≤0.016–2	0.06	0.5
De	CTB	0.06 to ≥64	16	≥64
	CTB/VNRX-5236	0.03–2	0.12	1
	CTB/CLA	0.06 to ≥64	4	32
	AMC	128 to ≥256	≥256	≥256
	Sulopenem	1 to ≥64	8	16
	Tebipenem	0.5 to ≥64	4	16

^aCTB, ceftibuten; CTB/VNRX-5236, ceftibuten with VNRX-5236 fixed at 4 μg/ml (boldface); CTB/CLA, ceftibuten with clavulanic acid fixed at 4 μg/ml; AMC, amoxicillin with clavulanic acid tested at a 2:1 ratio.

^bIncludes 12 strains of E. coli and 13 strains of K. pneumoniae.

^cIncludes 1 strain of E. coli, 19 strains of K. pneumoniae, 3 strains of E. cloacae, and 2 strains of Klebsiella oxytoca.

^dIncludes 7 strains of E. coli, 7 strains of K. pneumoniae, 3 strains of Klebsiella aerogenes, 6 strains of Serratia marcescens, 1 strain of Proteus mirabilis, and 1 strain of Citrobacter freundii.

^eIncludes 12 strain of E. coli and 13 strains of K. pneumoniae.