TABLE 5.

MICs of antimicrobial agents against strains utilized in time-kill studies^a

Antimicrobial agent	Organism, strain (β-lactamase content)
	E. coli ESBL4 (CTX-M-15)		E. cloacae ECL01 (TEM-72, ACT-1, P99AmpC)		K. pneumoniae ATCC BAA-1705 (KPC-2)		K. pneumoniae 752286 (OXA-48)
	MIC (μg/ml)	MBC (μg/ml)	MIC (μg/ml)	MBC (μg/ml)	MIC (μg/ml)	MBC (μg/ml)	MIC (μg/ml)	MBC (μg/ml)
CTB	32	>32	64	>32	16	16	128	≥128
CTB-CLA	0.12	1	≥256	≥256	8	16	16	16
CTB/VNRX-5236	0.12	0.12	0.25	1	0.12	0.25	0.25	0.25
AMC	16	16	128	≥128	≥256	≥256	≥256	≥256
Sulopenem	0.12	0.12	1	1	32	32	16	>32
Tebipenem	≤0.06	0.06	0.25	0.25	32	32	16	>32
Levofloxacin	32	32	0.12	0.12	64	≥64	32	>32

^aMICs represent modal broth microdilution values from 5 independent determinations. MBCs are the lowest concentrations of compound tested in the time-kill experiment at 24 h that resulted in a ≥3-log₁₀ CFU/ml reduction in bacterial counts from input. Shaded boxes represent data for the compound/pathogen combination shown in Fig. 3.