TABLE 7.

Impact of pH and human urine on activity of CTB/VNRX-5236^a

Strain	ID	Median or modal MIC (μg/ml)
		MHII broth		Human urine, pH 6		Human urine, pH 7.2
		CTB	CTB/VNRX-5236	CTB	CTB/VNRX-5236	CTB	CTB/VNRX-5236
E. coli	ATCC 25922	0.25	0.12	0.25	0.12	0.12	≤0.06
K. pneumoniae	ATCC 700603	0.5	0.25	1	0.5	0.5	0.12
K. pneumoniae	ATCC BAA-1705	8	0.25	2	0.5	2	≤0.06
K. pneumoniae	1434760	>128	0.5	>128	1	128	0.5
E. coli	1480076	128	0.25	32	0.5	32	0.12
K. pneumoniae	1266420	32	0.12	64	1	16	≤0.06

^aCTB, ceftibuten; CTB/VNRX-5236, ceftibuten with VNRX-5236 fixed at 4 μg/ml; MHII broth, cation-adjusted Mueller-Hinton broth.