TABLE 1.
MIC distributions of Trichophyton species (n = 135) against eight drugsa
| Species and parameter | Value (mg/liter) |
|||||||
|---|---|---|---|---|---|---|---|---|
| NAF | ITZ | MCZ | KTZ | TBF | SCZ | FCZ | GRI | |
| T. indotineae (n = 64) | ||||||||
| GM | 1.92 | 0.15 | 0.70 | 0.37 | 1.46 | 1.16 | 9.72 | 3.96 |
| MIC50 | 16.00 | 0.13 | 1.00 | 0.50 | >16 | 1.00 | 16.00 | 4.00 |
| MIC90 | >16 | 0.25 | 2.00 | 1.00 | >16 | 2.00 | >32 | 8.00 |
| Range | 0.016 to >16 | 0.016 to 2 | 0.125 to 4 | 0.063 to 4 | 0.016 to >16 | 0.25 to 2 | 0.5 to >32 | 2 to >32 |
| T. interdigitale (n = 36) | ||||||||
| GM | 0.06 | 0.13 | 0.40 | 0.32 | 0.02 | 1.47 | 1.92 | 2.12 |
| MIC50 | 0.06 | 0.13 | 0.25 | 0.25 | 0.02 | 2.00 | 2.00 | 2.00 |
| MIC90 | 0.06 | 0.25 | 1.00 | 1.00 | 0.03 | 2.00 | 8.00 | 4.00 |
| Range | 0.031 to 0.125 | 0.031 to 0.5 | 0.0625 to 2 | 0.125 to 2 | 0.016 to 0.0625 | 0.25 to 4 | 0.25 to 16 | 0.25 to 8 |
| T. mentagrophytes (n = 35) | ||||||||
| GM | 0.04 | 0.17 | 0.44 | 0.23 | 0.03 | 1.06 | 1.78 | 5.94 |
| MIC50 | 0.06 | 0.25 | 0.50 | 0.25 | 0.03 | 2.00 | 2.00 | 4.00 |
| MIC90 | 0.06 | 1.00 | 2.00 | 1.00 | 0.03 | 4.00 | 16.00 | >32 |
| Range | 0.016 to 0.0625 | 0.016 to 1 | 0.031 to 2 | 0.016 to 2 | 0.016 to 0.0625 | 0.0625 to 4 | 0.25 to 16 | 1 to >32 |
a
NAF, naftifine; ITZ, itraconazole; MCZ, miconazole; KTZ, ketoconazole; TBF, terbinafine; SCZ, sertaconazole; FCZ, fluconazole; GRI, griseofulvin; GM, geometric mean.