TABLE 3.
Comparison of AFST results after 10 sequential passages on PDA drug-free mediuma
| Parameter | Value (mg/liter) |
|||||||
|---|---|---|---|---|---|---|---|---|
| NAF | ITZ | MCZ | KTZ | TBF | SCZ | FCZ | GRI | |
| TBF-resistant species (n = 13) | ||||||||
| GM | >16 | 0.191 | 1.055 | 0.474 | >16 | 1.377 | 24.511 | 3.409 |
| MIC50 | >16 | 0.125 | 1 | 0.5 | >16 | 1 | 32 | 4 |
| MIC90 | >16 | 0.5 | 2 | 1 | >16 | 2 | >32 | 4 |
| Range | 16 to >16 | 0.0625 to 1 | 0.5 to 2 | 0.25 to 1 | >16 | 1 to 2 | 16 to >32 | 2 to 4 |
| Passage 10 times (n = 13) | ||||||||
| GM | >16 | 0.225 | 1.238 | 0.653 | >16 | 1.452 | 28.763 | 5.222 |
| MIC50 | >16 | 0.125 | 1 | 0.5 | >16 | 1 | 32 | 4 |
| MIC90 | >16 | 0.5 | 2 | 1 | >16 | 2 | >32 | 4 |
| Range | 16 to >16 | 0.0625 to 1 | 1 to 2 | 0.5 to 1 | >16 | 1 to 2 | 16 to >32 | 4 to 8 |
| TBF-susceptible species (n = 3) | ||||||||
| GM | 0.157 | 0.250 | 1.260 | 0.630 | 0.099 | 1.587 | 2.520 | 2.000 |
| Range | 0.0625 to 0.25 | 0.125 to 0.5 | 1 to 2 | 0.25 to 2 | 0.0625 to 0.125 | 1 to 2 | 2 to 4 | 2.000 |
| Passage 10 times (n = 3) | ||||||||
| GM | 0.157 | 0.250 | 1.000 | 0.315 | 0.099 | 2.000 | 0.500 | 3.175 |
| Range | 0.031 to 0.5 | 0.125 to 0.5 | 1.000 | 0.25 to 0.5 | 0.0625 to 0.125 | 1 to 4 | 0.500 | 2 to 4 |
a
The MICs of eight drugs show no statistical difference between 0 and 10 exposures.