TABLE 1.
IC50, CC50, and SI values for GSK717 and GSK583 at low MOIs (0.05 to 0.1)a
| Virusb | GSK717 |
GSK583 |
||||
|---|---|---|---|---|---|---|
| IC50 (μM) | CC50 (μM) | SI | IC50 (μM) | CC50 (μM) | SI | |
| ZIKV | 14.84 | 82.84 | 5.58 | 22.03 | 104.76 | 4.76 |
| DENV | 20.26 | 63.59 | 3.14 | 18.90 | 104.76 | 5.54 |
| MAYV | 12.69 | 63.59 | 5.01 | 19.85 | 104.76 | 5.28 |
| CVB5 | 9.57 | 81.95 | 8.56 | 0.11 | 104.76 | 952.36 |
| SARS-CoV-2 | 10.22 | 75.30 | 7.37 | 11.70 | 61.29 | 5.24 |
a
CC50, 50% cytotoxic concentration.
b
Results are from infected A549 (Zika virus [ZIKV], dengue virus 2 [DENV], coxsackievirus B5 [CVB5], or Mayaro virus [MAYV]) and ACE2-SK-N-SH (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) cells. Values for GSK717 were also determined using ZIKV-infected human fetal astrocytes. While GSK583 data were generated at 24 h, GSK717 values were generated at 24 h (CVB5) and 48 h (ZIKV, DENV-2, MAYV, and SARS-CoV-2).