TABLE 2.
IC50, CC50, and SI values for GSK717 and GSK583 at a high MOI (5)
| Virusa | GSK717 |
GSK583 |
||||
|---|---|---|---|---|---|---|
| IC50 (μM) | CC50 (μM) | SI | IC50 (μM) | CC50 (μM) | SI | |
| ZIKV | 17.87 | 82.84 | 4.64 | 24.24 | 104.76 | 4.32 |
| DENV | 19.39 | 63.59 | 3.28 | 22.72 | 104.76 | 4.61 |
| MAYV | 21.74 | 63.59 | 2.93 | 20.07 | 104.76 | 5.22 |
| SARS-CoV-2 | 14.38 | 75.30 | 5.24 | 17.95 | 61.29 | 3.41 |
a
Results are from infected A549 (Zika virus [ZIKV], dengue virus 2 [DENV], or Mayaro virus [MAYV]) and ACE2-SK-N-SH (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) cells. Values for GSK717 were also determined using ZIKV-infected human fetal astrocytes. For GSK583 and GSK717, the data were generated at 24 and 48 h, respectively.