FIG 1.

Changes in antibiogram in XDR parent variant to the pan-CS progeny variant. XDR (left) and pan-CS (right) pairs are displayed together. The drug to which the XDR variant was exposed to during cyclic therapy, the “treatment drug” (TD), is given under each pan-CS variant. The antibiotic disk size, 6 mm (dotted line), represents confluent bacterial growth up to the antibiotic disk. Zone of inhibition (ZOI) values (in mm) for each variant in shown for XDR (•) and pan-CS (○). Lines represent the change in sensitivity to each antibiotic (meropenem [MEM], ceftazidime [CAZ], levofloxacin [LVX], minocycline [MIN], chloramphenicol [CHL], and sulfamethoxazole-trimethoprim [SXT]), labeled at the pan-CS value. Lines with positive trends represent an increase in sensitivity, while lines with negative trends represent an increase in resistance. The steeper the slope of the connecting line, the greater the change in antibiotic sensitivity. Raw values can be found in Table S1 at https://pages.uncc.edu/todd-steck/aac00611-21-2/.