TABLE 1.
MICs of antimicrobials from different classes against ATCC 19606, ATCC 17978, and derived adeRS deletion strains
| Strain | MIC (mg/liter) ofa: |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMK | GEN | AZM | ERY | CIP | LVX | CHL | MEM | RIF | MIN | TET | TGCb | |
| ATCC 19606 | 8 | 16 | 32 | 32 | 1 | 0.5 | >128 | 0.5 | 4 | 0.25 | 8 | 1 |
| ATCC 19606 ΔadeRS | 2 | 8 | 2 | 16 | 0.5 | 0.25 | 128 | 0.25 | 4 | ≤0.125 | 4 | ≤0.125 |
| ATCC 17978 wild type | 2 | 1 | 2 | 16 | 0.25 | ≤0.125 | 64 | 0.5 | 4 | ≤0.125 | 1 | 0.25 |
| ATCC 17978 ΔadeRS | 2 | 1 | 2 | 16 | 0.25 | ≤0.125 | 64 | 0.5 | 4 | ≤0.125 | 1 | ≤0.125 |
| ATCC 17978 ΔadeRS(pJN17/04) | 2 | 0.5 | 2 | 8 | ≤0.125 | ≤0.125 | 64 | 0.5 | 4 | ≤0.125 | 1 | ≤0.125 |
| ATCC 17978 ΔadeRS(pJN17/04::adeRS17978) | 2 | 1 | 2 | 8 | ≤0.125 | ≤0.125 | 64 | 0.5 | 4 | ≤0.125 | 1 | ≤0.125 |
| ATCC 17978 ΔadeRS[pJN17/04::adeR(L172P)S17978] | 2 | 2 | 4 | 16 | 0.25 | ≤0.125 | 64 | 0.5 | 4 | ≤0.125 | 2 | ≤0.125 |
a
MICs were determined by agar dilution unless otherwise noted. AMK, amikacin; AZM, azithromycin; CHL, chloramphenicol; CIP, ciprofloxacin; ERY, erythromycin; GEN, gentamicin; MEM, meropenem; MIN, minocycline; LVX, levofloxacin; RIF, rifampicin; TET, tetracycline; TGC, tigecycline.
b
TGC MICs were determined by broth microdilution.