TABLE 1.

Pharmacokinetic parameters of delamanid after a single intravenous administration in mouse, rat, and dog^a

Parameterb	Value for:
	Mouse	Rat	Dog
Dose (mg/kg)	3	3	3
C0 (ng/ml)	1,198.9	13,923.4	1,320.6
AUCt (ng·h/ml)	13,388	21,551	13,822
AUC∞ (ng·h/ml)	13,491	21,566	14,140
t1/2 (h)	6.3	9.2	17.6
CL (ml/min/kg)	3.7	2.3	3.6
Vss (liter/kg)	2.3	1.7	5.3
MRT (h)	10.5	12.5	24.5

^aValues are the mean of n = 3 (mouse and rat) and n = 4 (dog).

^bC₀, predose concentration; AUC_t, area under the curve to the last data point.