TABLE 4.
Effect of extensive passaging of Candida species in the presence of sub-MICs of various antifungal compounds on the NP339 MIC
| Strain | Fold change in NP339 MIC at passage 30a |
|||
|---|---|---|---|---|
| NP339 | Caspofungin | Fluconazole | Amphotericin B | |
| C. albicans SC5314 | 1 | 1 | 1 | 1 |
| C. auris DSMZ1092 | 1 | 1 | 1 | 1 |
| C. glabrata AM2007/0125 | 0.031 | 0.062 | 1 | 1 |
| C. tropicalis AM2005/0568 | 1 | 1 | 1 | 1 |
a
The MIC of NP339 at passage 0 was normalized to 1, and the fold change in the MIC of NP339 after 30 passages in 0.25× MIC of the indicated antifungal was calculated. A value of 1 signifies no change. The data are averages from three independent replicates.