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The chemical tools in chromatin biology. (a) Schematic representation of chromatin architecture in the eukaryotic genome and the proteins that install, remove, and sense epigenetic modifications on histone proteins and DNA. (b) Overview of the chemical tools for studying chromatin. The structure of the mononucleosome depicts DNA (gray) wrapped around two copies each of histones H2A (yellow), H2B (red), H3 (blue) and H4 (green). PDB, 1kx5.
