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. Author manuscript; available in PMC: 2022 Jun 20.
Published in final edited form as: Annu Rev Biochem. 2021 Jun 20;90:287–320. doi: 10.1146/annurev-biochem-080120-021109

Figure 3.

Figure 3

Tools based on nucleic acid synthesis. (a) Overview of oligonucleotide probes that can be generated by chemical and enzymatic DNA synthesis approaches. (b) Genomic profiling of 5-hmC by selective tagging with biorthogonal sugars. (c) Incorporation of photolabile precursors for the generation of apurinic/apyrimidinic (AP) sites in situ. ONV, o-nitroveratrole. (d) DNA nicking and gap-filling strategy for the incorporation of modified oligos into chromatin array DNA substrates.