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. 2021 Jun 16;13(6):e15694. doi: 10.7759/cureus.15694

Table 2. Summary of molecular imaging.

PCA: posterior cortical atrophy; HV: healthy variants; AD: Alzheimer's disease; DLB: Dementia with Lewy bodies; PDD: Parkinson's disease with dementia; CIS: Cingulate island sign; FDG-PET: fluorine-18-fluorodeoxyglucose positron emission imaging; MMSE: Mini-Mental State Examination; MRI: magnetic resonance imaging; AV-1451: 18F-flortaucipir; PiB-PET: Pittsburgh compound B(PiB) positron emission tomography

Author Study performed Subject Findings
Gupta et al. FDG-PET 34 PCA, 38 DLB Cerebral hypometabolism was found to be localized in the occipital cortex in DLB patients [15].
Klein et al. FDG-PET 6 DLB, 8 PDD, 9 PD without dementia Both DLB and PDD groups showed cerebral hypometabolism without significant differences amongst them, while PD patients without dementia didn’t show FDG binding reductions [16].
Perneczky et al. FDG-PET 14 DLB with visual hallucination, 7 DLB without visual hallucination, 16 HV The extent of hypometabolism in visual association areas is associated with symptoms of visual hallucination [24].
Iizuka et al. FDG-PET, MRI with voxel-based morphometry 24 DLB, 24 AD Higher CIS ratio in DLB compared to AD, which is associated with symptoms of visual hallucinations with CIS [18].
Kantarci et al. PiB-PET 14 DLB, 6 AD, 19 mixed pathology of DLB and AD Lower PiB retention in DLB patients compared to the groups with AD or mixed pathology [19].
Edison et al. PiB-PET 13 DLB, 12 PDD, 10 PD without dementia, 41 HV Higher PiB retention in over 80% of subjects with DLB compared to other subjects, signifying the role of amyloid-related pathology in DLB patients [20].
Kantarci et al. AV-1451, PiB-PET 19 DLB, 19 AD, 95 HV AD group showed higher medial temporal AV-1451 uptake than DLB. DLB group showed higher AV-1451 uptake compared to healthy variants suggesting the role of tau pathology in DLB [21].
Gomperts et al. AV-1451, PiB-PET 7 DLB, 8 PDD, 9 PD without dementia, 29 HV Higher AV-1451 uptake was found in the inferior temporal gyrus and precuneus in DLB and higher AV-1451 uptake was linked to lower MMSE scores [22].
Maetzler et al. PiB-PET 9 DLB, 12 PDD, 14 PD without dementia A greater extent of PiB binding was found to be associated with a worse MMSE score [23].