Author |
Study performed |
Subject |
Findings |
Gupta et al. |
FDG-PET |
34 PCA, 38 DLB |
Cerebral hypometabolism was found to be localized in the occipital cortex in DLB patients [15]. |
Klein et al. |
FDG-PET |
6 DLB, 8 PDD, 9 PD without dementia |
Both DLB and PDD groups showed cerebral hypometabolism without significant differences amongst them, while PD patients without dementia didn’t show FDG binding reductions [16]. |
Perneczky et al. |
FDG-PET |
14 DLB with visual hallucination, 7 DLB without visual hallucination, 16 HV |
The extent of hypometabolism in visual association areas is associated with symptoms of visual hallucination [24]. |
Iizuka et al. |
FDG-PET, MRI with voxel-based morphometry |
24 DLB, 24 AD |
Higher CIS ratio in DLB compared to AD, which is associated with symptoms of visual hallucinations with CIS [18]. |
Kantarci et al. |
PiB-PET |
14 DLB, 6 AD, 19 mixed pathology of DLB and AD |
Lower PiB retention in DLB patients compared to the groups with AD or mixed pathology [19]. |
Edison et al. |
PiB-PET |
13 DLB, 12 PDD, 10 PD without dementia, 41 HV |
Higher PiB retention in over 80% of subjects with DLB compared to other subjects, signifying the role of amyloid-related pathology in DLB patients [20]. |
Kantarci et al. |
AV-1451, PiB-PET |
19 DLB, 19 AD, 95 HV |
AD group showed higher medial temporal AV-1451 uptake than DLB. DLB group showed higher AV-1451 uptake compared to healthy variants suggesting the role of tau pathology in DLB [21]. |
Gomperts et al. |
AV-1451, PiB-PET |
7 DLB, 8 PDD, 9 PD without dementia, 29 HV |
Higher AV-1451 uptake was found in the inferior temporal gyrus and precuneus in DLB and higher AV-1451 uptake was linked to lower MMSE scores [22]. |
Maetzler et al. |
PiB-PET |
9 DLB, 12 PDD, 14 PD without dementia |
A greater extent of PiB binding was found to be associated with a worse MMSE score [23]. |