Table 3. Summary of findings in dopamine transporter imaging (DAT).

[123I]FP- CIT-SPECT: Iodine 123-radiolabeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single-photon emission tomography

HV: healthy variants; AD: Alzheimer's disease; DLB: dementia with Lewy bodies; PDD: Parkinson's disease with dementia; CIS: Cingulate island sign; FA: fractional anisotropy; MMSE: Mini-Mental State Examination; MRI: magnetic resonance imaging; FTD: frontotemporal dementia

Author	Study	Subjects	Summary of findings
O’Brien et al.	[123I]FP- CIT-SPECT	33HV, 34 AD, 23 DLB, 38 PD without dementia, 36 PDD	Markedly reduced FP-CIT binding in the caudate and anterior and posterior putamen in DLB when compared to AD and HV [26].
Walker et al.	[123I]FP- CIT-SPECT	Eight DLB, nine AD, three other pathology	[123I]FP- CIT-SPECT significantly increased the diagnostic accuracy while differentiating between DLB and other pathologies with a sensitivity of 88% and specificity of 100% [27].
McKeith et al.	[123I]FP- CIT-SPECT	94 probable DLB, 57 possible DLB 147 non-DLB dementia, 28 patients without any diagnosis	Low DAT binding evaluated by [123I]FP- CIT-SPECT has a very high diagnostic correlation with a diagnosis of DLB [28].
Pardini et al.	[123I]FP- CIT-SPECT	12 HV, 18 DLB, 21 AD	Higher nigroputaminal FA values in DLB patients compared to AD and HV [25].
Chang et al.	99mTc-ethyl cysteinate dimer (ECD) SPECT	17 DLB, 16 PD, 10 HV	DLB group showed marked hypoperfusion in the frontal, parietal, thalamus, temporal regions when compared to HV [29].
Morgan et al.	[123I]FP- CIT-SPECT	12 FTD, 10 DLB, 9 AD	While SPECT scan displayed an excellent specificity of 89% in the AD group, in the FTD group the specificity reduced to 67% [30].