Table 4:
Biomarker Performance in identification of progression or response to therapy relative to contemporaneous RECIST criteria
Predictor | Dependent | P value |
---|---|---|
GP88 | progression | 0.0101 |
GP88 | Response | 0.0194 |
CA15-3 | progression | <0.0001 |
CA15-3 | Response | 0.7316 |
The two biomarkers were tested for association with contemporaneous RECIST assessment of disease progression (PD) and response to therapy (R). The values of these predictors were tested for statistical significance of the difference between the two groups using the Wilcoxon test. Table 4 shows that the contemporaneous GP88 is highly significantly associated with disease progression and response while CA15–3 is only significant in conjunction with progression.