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(a) Simplified electrostatic repulsion and (b) simplified free energy diagram of aggregation pathway according to Lumry‐Eyring model for a protein near and far from its pI. In the Lumry‐Eyring model, folded monomer unfolds reversibly and then the unfolded monomer aggregates irreversibly. The aggregation step is usually expected to be the rate‐determining step in a non‐accelerated storage condition 54
