TABLE 1.
Characteristics of Malawi Sickle Surveillance Study participants in the Central region of Malawi, 2018, stratified by sickle cell, α-thalassemia, and G6PD status. Clinical data were linked with hemoglobin electrophoresis and PCR results from dried blood spots obtained from infants ≤6 weeks of age from Malawi’s HIV Early Infant Diagnosis program. Bold values are absolute number of infants and percentage in brackets.
| Sickle cell | α-thalassemia | G6PD males | G6PD females | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SCD n (%) | SCT n (%) | Normal n (%) | Total n (%) | 2 copies -α/-α n (%) | 3 copies -α/αα n (%) | 4 copies αα/αα n (%) | Total n (%) | Deficient: A n (%) | Normal: G n (%) | Total n (%) | Deficient: A n (%) | Carriers: AG n (%) | Normal: G n (%) | Total n (%) | |
| Sample size | 14 (0.1) | 741 (7.0) | 9,774 (92.8) | 10,529 | 102 (7.7) | 506 (38.1) | 721 (54.3) | 1,329 | 134 (20.4) | 523 (79.6) | 657 | 23 (3.4) | 198 (29.0) | 462 (67.6) | 683 |
| Sex | |||||||||||||||
| Female | 4 (0.1) | 376 (7.3) | 4,797 (92.7) | 5,177 (49.2) | 55 (8.1) | 264 (38.9) | 359 (52.9) | 678 (51.0) | — | — | — | — | — | — | — |
| Male | 10 (0.2) | 344 (6.8) | 4,728 (93.0) | 5,082 (48.3) | 47 (7.2) | 242 (37.2) | 362 (55.6) | 651 (49.0) | — | — | — | — | — | — | — |
| Not provided | 0 (0.0) | 21 (7.8) | 249 (92.2) | 270 (2.6) | — | — | — | — | — | — | — | — | — | — | — |
| HIV status | |||||||||||||||
| Positive | 0 (0.0) | 43 (7.5) | 532 (92.5) | 575 (5.5) | 5 (8.2) | 22 (36.1) | 34 (55.7) | 61 (4.6) | 8 (32.0) | 17 (68.0) | 25 (3.8) | 2 (5.4) | 10 (27.0) | 25 (67.6) | 37 (5.4) |
| Negative | 14 (0.1) | 670 (7.0) | 8,931 (92.9) | 9,615 (91.3) | 95 (7.8) | 463 (38.0) | 662 (54.3) | 1,220 (91.8) | 121 (19.8) | 489 (80.2) | 610 (92.8) | 20 (3.2) | 180 (29.0) | 420 (67.7) | 620 (90.8) |
| Unknown a | 0 (0.0) | 28 (16.9) | 311 (91.7) | 339 (0.0) | 2 (4.2) | 21 (43.8) | 25 (52.1) | 48 (3.6) | 5 (22.7) | 17 (77.3) | 22 (3.3) | 1 (3.8) | 8 (30.8) | 17 (65.4) | 26 (3.8) |
a
Indeterminate, discordant, new sample to be collected, blank.