TABLE 2.
Prevalence of inherited hematological disorders in the Malawi Sickle Surveillance Study, stratified by district in the Central region of Malawi, 2018. Historical malaria prevalence estimates, (Plasmodium falciparum in children ages 1–10) are taken from data from 1970 to 2001 at 73 survey locations across Malawi [18]. Bold values are absolute number of infants and percentage in brackets.
| Malaria | Sickle cell | α-thalassemia a | G6PD males b | G6PD females c | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| District | Prevalence 1970–2001 | SCD n (%) | SCT n (%) | Normal n (%) | Total n (%) | 2 copies -α/-α n (%) | 3 copies -α/αα n (%) | 4 copies αα/αα n (%) | Total n (%) | Deficient: A n (%) | Normal: G n (%) | Total n (%) | Deficient: A n (%) | Carriers: AG n (%) | Normal: G n (%) | Total n (%) | |
| 1 | Dedza | 0.50 | 0 (0.0) | 28 (3.9) | 684 (96.1) | 712 (6.8) | 12 (9.6) | 45 (36.0) | 68 (54.4) | 125 (9.4) | 12 (21.4) | 44 (78.6) | 56 (8.5) | 1 (1.4) | 17 (24.6) | 51 (73.9) | 69 (10.1) |
| 2 | Dowa | 0.87 | 0 (0.0) | 24 (6.6) | 341 (93.4) | 365 (3.5) | 6 (5.0) | 46 (38.7) | 67 (56.3) | 119 (9.0) | 16 (26.2) | 45 (73.8) | 61 (9.3) | 2 (3.4) | 13 (22.0) | 44 (74.6) | 59 (8.6) |
| 3 | Kasungu | 0.53 | 0 (0.0) | 70 (9.7) | 650 (90.3) | 720 (6.8) | 14 (9.6) | 49 (33.6) | 83 (56.8) | 146 (11.0) | 12 (17.6) | 56 (82.4) | 68 (10.4) | 4 (5.1) | 17 (21.5) | 58 (73.4) | 79 (11.6) |
| 4 | Lilongwe | 0.59 | 12 (0.3) | 318 (6.7) | 4,427 (93.1) | 4,757 (45.2) | 18 (8.6) | 82 (39.2) | 109 (52.2) | 209 (15.7) | 15 (14.0) | 92 (86.0) | 107 (16.3) | 3 (2.9) | 29 (28.2) | 71 (68.9) | 103 (15.1) |
| 5 | Mchinji | 0.50 | 1 (0.1) | 110 (9.6) | 1,039 (90.3) | 1,150 (10.9) | 14 (7.6) | 69 (37.5) | 101 (54.9) | 184 (13.8) | 17 (19.5) | 70 (80.5) | 87 (13.2) | 3 (3.1) | 30 (30.6) | 65 (66.3) | 98 (14.3) |
| 6 | Nkhotakota | 0.44 | 0 (0.0) | 29 (7.3) | 366 (92.7) | 395 (3.8) | 6 (5.3) | 44 (38.9) | 63 (55.8) | 113 (8.5) | 14 (24.6) | 43 (75.4) | 57 (8.7) | 1 (1.8) | 20 (35.1) | 36 (63.2) | 57 (8.3) |
| 7 | Ntcheu | 0.43 | 1 (0.1) | 42 (4.4) | 906 (95.5) | 949 (9.0) | 9 (6.6) | 47 (34.6) | 80 (58.8) | 136 (10.2) | 11 (15.9) | 58 (84.1) | 69 (10.5) | 2 (2.9) | 24 (34.8) | 43 (62.3) | 69 (10.1) |
| 8 | Ntchisi | NA | 0 (0.0) | 14 (8.9) | 143 (91.1) | 157 (1.5) | 11 (9.7) | 42 (37.2) | 60 (53.1) | 113 (8.5) | 14 (25.0) | 42 (75.0) | 56 (8.5) | 1 (1.8) | 12 (21.1) | 44 (77.2) | 57 (8.3) |
| 9 | Salima | 0.87 | 0 (0.0) | 106 (8.0) | 1,218 (92.0) | 1,324 (12.6) | 12 (6.5) | 82 (44.6) | 90 (48.9) | 184 (13.8) | 23 (24.0) | 73 (76.0) | 96 (14.6) | 6 (6.5) | 36 (39.1) | 50 (54.3) | 92 (13.5) |
a
n tested = 1,329.
b
n tested = 657.
c
n tested = 683.