TABLE 3.
Sickle cell disease, sickle cell trait, α-thalassemia deficiency, and G6PD deficiency and carrier status prevalence estimates among Malawi Sickle Surveillance study participants, 2018, stratified by genotype.
| α-thalassemia a | G6PD males b | G6PD females c | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 copies -α/-α n (%) | 3 copies -α/αα n (%) | 4 copies αα/αα n (%) | Total n (%) | Deficient: A n (%) | Normal: G n (%) | Total n (%) | Deficient: A n (%) | Carrier: AG n (%) | Normal: G n (%) | Total n (%) | ||
| Sickle cell | Disease | 1 (7.7) | 3 (23.1) | 9 (69.2) | 13 (1.0) | 2 (22.2) | 7 (77.8) | 9 (1.4) | — | — | 4 (100.0) | 4 (0.6) |
| Trait | 32 (7.3) | 167 (38.2) | 238 (54.5) | 437 (32.9) | 35 (16.7) | 174 (83.3) | 209 (31.8) | 9 (3.8) | 68 (29.1) | 157 (67.1) | 234 (34.3) | |
| Normal | 69 (7.8) | 336 (38.2) | 474 (53.9) | 879 (66.1) | 97 (22.1) | 342 (77.9) | 439 (66.8) | 14 (3.1) | 130 (29.2) | 301 (67.6) | 445 (65.2) | |
| α-thalassemia | -α/-α | — | — | — | — | 9 (19.1) | 38 (80.9) | 47 (7.2) | 3 (5.5) | 17 (30.9) | 35 (63.6) | 55 (8.1) |
| -α /αα | — | — | — | — | 45 (18.6) | 197 (81.4) | 242 (36.8) | 10 (3.8) | 75 (28.4) | 179 (67.8) | 264 (38.7) | |
| αα/αα | — | — | — | — | 80 (22.1) | 282 (77.9) | 362 (55.1) | 10 (2.8) | 102 (28.4) | 247 (68.8) | 359 (52.6) | |
| No score | — | — | — | — | — | 6 (100.0) | 6 (0.9) | — | 4 (80.0) | 1 (20.0) | 5 (0.7) | |
a
n tested = 1,329.
b
n tested = 657.
c
n tested = 683.