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. 2021 Jun 1;3(1):vdab072. doi: 10.1093/noajnl/vdab072

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© The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — IL-8 and ICOSLG levels in patient plasma and cell line conditioned media from 8 patients and paired cell lines are shown in (A) and (B). In (C) association between CXCL8, ICOSLG RNA expression and OS in TCGA LGG and GBM datasets are illustrated using Cox proportional hazards regression. Cell line CXCL8 and ICOSLG RNA expression in (D). (E) depicts RNA expression of CXCL8 and ICOSLG in GBM single cells¹⁴ and (F) depicts RNA expression of CXCL8 in purified cells from human brain.¹³ In (F) astrocytes include mature astrocytes, fetal astrocytes, and astrocytes from sclerotic hippocampi and GBM. One-unit increase in NPX corresponds to a 2-fold increase in protein abundance. CM, conditioned media; CXCL8, C-X-C Motif Chemokine Ligand 8; GBM, glioblastoma; ICOSLG, ICOS ligand; IL-8, interleukin-8; LGG, low-grade glioma; LOD, limit of detection; NPX, Normalized Protein Expression; OS, overall survival.