Table 1. Results of the screening process (rates, sensitivity, specificity) and change in rates vs cut-off 20μg/g.
| Cut-off value μg/g of feces | CRC | Sensitivity | Specificity | PPV | FP | IC_test | SC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes | No | % | 95%CI | % | 95%CI | % | 95%CI | Rate % | change vs. 20 | Rate ‰ | change vs. 20 | Rate ‰ | change vs. 20 | ||
| O1 | Positive | 1,981 | 38,132 | 90.7 | (89.44–91.88) | 93.0 | (92.91–93.05) | 4.9 | (4.73–5.15) | 6.99 | 0.54* | 0.37 | -0.03 | 3.63 | 0.02 |
| Negative | 204 | 505,190 | |||||||||||||
| O2 | Positive | 1,970 | 35,365 | 90.2 | (88.91–91.41) | 93.5 | (93.43–93.56) | 5.3 | (5.05–5.50) | 6.48 | 0.03 | 0.39 | -0.01 | 3.61 | 0 |
| Negative | 215 | 507,957 | |||||||||||||
| 20 | Positive | 1,969 | 35,211 | 90.1 | (88.86–91.37) | 93.5 | (93.45–93.58) | 5.3 | (5.07–5.52) | 6.45 | 0.40 | 3.61 | |||
| Negative | 216 | 508,109 | |||||||||||||
| 25 | Positive | 1,881 | 29,335 | 86.1 | (84.64–87.54) | 94.6 | (94.54–94.66) | 6.0 | (5.76–6.29) | 5.38 | -1.07* | 0.56 | 0.16* | 3.45 | -0.16 |
| Negative | 304 | 513,985 | |||||||||||||
| 30 | Positive | 1,828 | 26,037 | 83.7 | (82.11–85.21) | 95.2 | (95.15–95.26) | 6.6 | (6.27–6.85) | 4.77 | -1.68* | 0.65 | 0.25* | 3.35 | -0.26* |
| Negative | 357 | 517,283 | |||||||||||||
| 35 | Positive | 1,789 | 23,524 | 81.9 | (80.26–83.49) | 95.7 | (95.62–95.72) | 7.1 | (6.75–7.38) | 4.31 | -2.14* | 0.73 | 0.33* | 3.28 | -0.33* |
| Negative | 396 | 519,796 | |||||||||||||
| 40 | Positive | 1,737 | 21,594 | 79.5 | (77.80–81.79) | 96.0 | (95.97–96.08) | 7.5 | (7.11–7.78) | 3.96 | -2.49* | 0.82 | 0.42* | 3.18 | -0.43* |
| Negative | 448 | 521,726 | |||||||||||||
CRC, Colorectal cancer; PPV, positive predictive value; FP, false positive; IC_test, test interval cancer; SC, screening cancer rates; O1, different optimal cut-off value for each age and sex group, 18.35μg/g in women aged 50–59, 14.60μg/g in women aged 60–69, 16.78μg/g in men aged 50–59, and 19.91μg/g in men aged 60–69; O2, optimal cut-off value of 19.73μg/g for the total sample; CI, confidence interval.
*p_valor<0.05.