Table 2.
Univariate and multivariate analysis to identify interdependent influential factors of dense breast in training set.
| Univariate analysis | Multivariate analysis | |||
| Variables | OR (95% CI) | P value | OR (95% CI) | P value |
| Age duration | ||||
| 40–44 | 1 | 1 | ||
| 45–49 | 0.68 (0.51–0.91) | .009 | 0.79 (0.59–1.06) | .120 |
| 50–54 | 0.38 (0.29–0.50) | <.001 | 0.71 (0.51–0.98) | .038 |
| 55–59 | 0.21 (0.16–0.28) | <.001 | 0.51 (0.36–0.73) | <.001 |
| 60–64 | 0.13 (0.10–0.18) | <.001 | 0.33 (0.23–0.48) | <.001 |
| 64–69 | 0.07 (0.04–1.12) | <.001 | 0.18 (0.10–0.32) | <.001 |
| Marital status | ||||
| Unmarried | 1 | |||
| Married | 0.91 (0.61–1.37) | .647 | ||
| Divorce | 1.02 (0.57–1.84) | .947 | ||
| Widowed | 0.58 (0.30–1.12) | .106 | ||
| Educational attainment | ||||
| Primary or less | 1 | 1 | ||
| Secondary | 1.24 (0.94–1.66) | .135 | 1.34 (0.98–1.85) | .070 |
| Tertiary | 1.87 (1.42–2.46) | <.001 | 1.53 (1.12–2.08) | .008 |
| Breast cancer family history | ||||
| No | 1 | |||
| Yes | 1.32 (0.92–1.89) | .129 | ||
| History of benign breast diseases | ||||
| No | 1 | 1 | ||
| Yes | 2.09 (1.52–2.87) | <.001 | 2.06 (1.47–2.90) | <.001 |
| Age at menarche (yr) | ||||
| ≤12 | 1 | |||
| >12 | 0.82 (0.64–1.04) | .101 | ||
| Breastfeeding history | ||||
| No | 1 | 1 | ||
| Yes | 0.78 (0.65–0.93) | .007 | 0.78 (0.63–0.95) | .013 |
| Number of birth | ||||
| 0 | 1 | 1 | ||
| 1 | 1.60 (1.37–1.86) | <.001 | 0.98 (0.82–1.16) | .785 |
| ≥2 | 1.13 (0.89–1.44) | .302 | 0.89 (0.68–1.15) | .365 |
| Menopause status | ||||
| Premenopausal | 1 | 1 | ||
| Postmenopausal | 0.26 (0.23–0.30) | <.001 | 0.42 (0.33–0.53) | <.001 |
| Menopause age | ||||
| ≤50 | 1 | |||
| >50 | 1.15 (0.97–1.37) | .119 | ||
| Menopause ways | ||||
| Induced menopause | 1 | |||
| Natural menopause | 1.23 (0.80–1.88) | .345 | ||
| Plasma glucose (mmol/L) | ||||
| ≤6.1 | 1 | 1 | ||
| >6.1 | 0.63 (0.52–0.76) | <.001 | 0.89 (0.73–1.10) | .290 |
| BMI (kg/m2) | ||||
| <18.5 | 1 | 1 | ||
| 18.5–24.9 | 0.65 (0.33–1.29) | .221 | 0.73 (0.36–1.50) | .390 |
| 25.0–29.9 | 0.35 (0.17–0.69) | .003 | 0.41 (0.20–0.83) | .014 |
| ≥30.0 | 0.32 (0.14–0.71) | .005 | 0.36 (0.15–0.86) | .020 |
| Smoke | ||||
| No | 1 | 1 | ||
| Yes | 0.71 (0.58–0.87) | .001 | 0.87 (0.69–1.11) | .270 |
| Drink | ||||
| No | 1 | |||
| Yes | 0.96 (0.79–1.16) | .681 | ||
| Fruit intake (kg/wk) | ||||
| Never | 1 | |||
| ≤1.25 | 1.43 (1.02–2.01) | .038 | 0.90 (0.57–1.43) | .664 |
| >1.25 | 1.73 (1.22–2.44) | .002 | 1.02 (0.61–1.72) | .930 |
| Vegetable intake (kg/wk) | ||||
| Never | 1 | 1 | ||
| ≤2.5 | 1.35 (0.95–1.92) | .091 | 1.27 (0.81–2.02) | .300 |
| >2.5 | 1.48 (1.04–2.12) | .029 | 1.43 (0.87–2.35) | .158 |
| Meat intake (kg/wk) | ||||
| Never | 1 | |||
| ≤0.35 | 1.17 (0.83–1.64) | .369 | ||
| >0.35 | 1.30 (0.90–1.87) | .161 | ||
| Coarse grains intake (kg/wk) | ||||
| Never | 1 | 1 | ||
| ≤0.35 | 1.31 (1.07–1.60) | .008 | 1.22 (0.93–1.58) | .150 |
| >0.35 | 1.26 (0.95–1.65) | .104 | 0.95 (0.68–1.33) | .780 |
| Exercise (h/wk) | ||||
| ≤1 | 1 | |||
| >1 | 0.91 (0.75–1.10) | .307 | ||
| Region | ||||
| Urban | 1 | 1 | ||
| Rural | 1.15 (1.01–1.31) | .033 | 0.88 (0.74–1.04) | .142 |
BI-RADS = the American College of Radiology's Breast Imaging Reporting and Data System, BMI = body mass index, OR = odds ratio.