Table 2.
The pooled baseline characteristics results of comparison between TAVR and SAVR for severe AS.
| Pooled results | Heterogeneity | ||||||
| Subgroups | No. of study/pts | RR | 95% CI | P | I2 | Ph | Analytical effect model |
| DM | 7/6772 | RR 0.96 | 0.90–1.03 | .25 | 29% | .21 | Fixed-effects model |
| Serum Cr >2 mg/dL | 6/6022 | RR 0.88 | 0.56–1.38 | .57 | 0% | .80 | Fixed-effects model |
| Previous stroke | 5/5058 | RR 0.88 | 0.72–1.07 | .20 | 0% | .86 | Fixed-effects model |
| Previous TIA | 4/4718 | RR 1.09 | 0.88–1.34 | .44 | 0% | .86 | Fixed-effects model |
| PVD | 8/7405 | RR 1.0 | 0.93–1.08 | 1.00 | 0% | .97 | Fixed-effects model |
| Previous PM | 5/7354 | RR 1.0 | 0.87–1.14 | .97 | 0% | .92 | Fixed-effects model |
| CAD | 5/5671 | RR 0.96 | 0.92–1.0 | .04 | 16% | .31 | Fixed-effects model |
| Previous CABG | 5/6124 | RR 0.94 | 0.85–1.04 | .25 | 0% | .97 | Fixed-effects model |
| Previous PCI | 6/6395 | RR 1.0 | 0.91–1.09 | .99 | 0% | .89 | Fixed-effects model |
| Previous MI | 6/6700 | RR 1.06 | 0.93–1.20 | .40 | 0% | .88 | Fixed-effects model |
| CHF | 2/3320 | RR 0.98 | 0.97–1.00 | .02 | 0% | .64 | Fixed-effects model |
| History of arrhythmia | 2/3320 | RR 1.01 | 0.92–1.12 | .79 | 0% | 1.0 | Fixed-effects model |
| AF | 7/7271 | RR 0.96 | 0.89–1.04 | .32 | 2% | .41 | Fixed-effects model |
| NYHA Class III/IV | 7/7358 | RR 1.01 | 0.96–1.06 | .66 | 50% | .06 | Random-effect model |
| CVD | 4/2358 | RR 0.97 | 0.81–1.17 | .78 | 0% | .76 | Fixed-effects model |
| COPD | 5/3092 | RR 0.91 | 0.80–1.03 | .14 | 0% | .74 | Fixed-effects model |
| LVEF (%) | 5/3986 | MD–0.39 | −0.94–0.15 | .16 | 0% | .95 | Fixed-effects model |
| Aortic valve area, cm2 | 4/3080 | MD 0.02 | −0.04–0.07 | .51 | 91% | <.0001 | Random-effect model |
| Aortic-valve peak gradient, mmHg | 4/3080 | MD 0.64 | −1.11–2.38 | .48 | 63% | .05 | Random-effect model |
| PH | 2/1563 | RR 1.02 | 0.88–1.19 | .76 | 0% | .54 | Fixed-effects model |
| Hypertension | 4/4091 | RR 1.01 | 0.99–1.04 | .23 | 20% | .36 | Fixed-effects model |
AF = atrial fibrillation, AS = aortic stenosis, CABG = coronary-artery bypass grafting, CAD = coronary artery disease, CHF = congestive heart failure, CI = confidence interval, COPD = chronic obstructive pulmonary disease, Cr = creatinine, CVD = cerebral vascular disease, DM = diabetes mellitus, LVEF = left ventricular ejection fraction, MI = myocardial infarction, PCI = percutaneous coronary intervention, PH = pulmonary hypertension, PM = pacemaker, PVD = peripheral vascular disease, RR = risk ratio, SAVR = surgical aortic valve replacement, TAVR = transcatheter aortic valve replacement, TIA = transient ischemic attacks.