Table 4.

The pooled results of comparison between TAVR and SAVR for severe AS regarding to the 1-year outcomes.

		Pooled results			Heterogeneity
Subgroups	No. of study/pts	RR	95% CI	P	I2	Ph	Analytical effect model
Bleeding	5/6744	0.41	0.24–0.68	.0007	93%	<.0001	Random-effect model
All AKI	3/4642	0.44	0.25–0.77	.004	68%	.05	Random-effect model
AKI >stage 2	4/6045	0.56	0.40–0.77	.0004	49%	.12	Fixedeffects model
Cardiogenic shock	1/1660	0.32	0.16–0.65	.002
Neurological events	4/6755	3.01	1.72–5.27	.0001	0%	.46	Fixed-effects model
TIA	7/8680	1.44	1.07–1.95	.02	0%	.88	Fixed-effects model
Major vascular complications	4/5794	2.23	1.19–4.18	.01	83%	.0006	Random-effect model
Permanent PM	6/7020	2.32	1.36–3.95	.002	91%	<.0001	Random-effect model
All-cause mortality	10/9790	0.94	0.84–1.06	.33	0%	.65	Fixed-effects model
CV mortality	6/7277	0.91	0.76–1.09	.30	0%	.52	Fixed-effects model
Stroke	7/8680	0.89	0.75–1.06	.18	38%	.14	Fixed-effects model
Reintervention	3/3968	0.96	0.78–1.18	.67	0%	.42	Fixed-effects model
MI	7/8680	0.91	0.67–1.23	.53	0%	.64	Fixed-effects model
Endocarditis	5/6070	0.82	0.42–1.58	.55	0%	.55	Fixed-effects model
Rehospitalization	6/8404	0.94	0.75–1.18	.60	64%	.02	Random-effect model
Aortic regurgitation	2/1852	1.72	0.88–3.34	.11	0%	.65	Fixed-effects model
CAD	2/3435	1.19	0.49–2.88	.70	36%	.21	Fixed-effects model

AKI = acute kidney injury, AS = aortic stenosis, CAD = coronary artery disease, CI = confidence interval, CV = cardiovascular, LVEF = left ventricular ejection fraction, MI = myocardial infarction, NOAF = new-onset atrial fibrillation, PM = pacemaker, RF = renal failure, RR = risk ratio, SAVR = surgical aortic valve replacement, TAVR = transcatheter aortic valve replacement, TIA = transient ischemic attacks.