Table 5.
The pooled results of comparison between TAVR and SAVR for severe AS regarding to the 2-year outcomes.
| Pooled results | Heterogeneity | ||||||
| Subgroups | No. of study/pts | RR | 95% CI | P | I2 | Ph | Analytical effect model |
| Permanent PM | 4/3441 | 2.61 | 1.36–5.00 | .004 | 90% | <.00001 | Random-effect model |
| Rehospitalization | 2/3692 | 1.25 | 1.06–1.46 | .007 | 0% | .41 | Fixed effects model |
| Major vascular complications | 3/3165 | 2.38 | 1.26–4.49 | .007 | 58% | .09 | Random-effect model |
| Neurological events | 3/2965 | 1.26 | 1.02–1.57 | .04 | 0% | .47 | Fixed effects model |
| TIA | 5/5375 | 1.58 | 1.14–2.17 | .006 | 0% | .97 | Fixed effects model |
| Reintervention | 2/3692 | 3.22 | 1.64–6.29 | .0006 | 0% | .62 | Fixed effects model |
| All-cause mortality | 6/5758 | 0.92 | 0.83–1.03 | .16 | 34% | .18 | Fixed effects model |
| CV mortality | 5/5101 | 0.87 | 0.74–1.02 | .09 | 0% | .55 | Fixed effects model |
| Stroke | 5/5101 | 0.85 | 0.71–1.02 | .09 | 14% | .33 | Fixed effects model |
| MI | 4/4718 | 0.98 | 0.71–1.36 | .90 | 0% | .85 | Fixed effects model |
| Bleeding | 3/3165 | 0.56 | 0.31–1.00 | .05 | 96% | <.00001 | Random-effect model |
| All AKI | 3/3165 | 0.63 | 0.31–1.30 | .21 | 70% | .04 | Random-effect model |
AKI = acute kidney injury, AS = aortic stenosis, CAD = coronary artery disease, CI = confidence intervals, CV = cardiovascular, NOAF = new-onset atrial fibrillation, RR = risk ratio, SAVR = surgical aortic valve replacement, TAVR = transcatheter aortic valve replacement, TIA = transient ischemic attacks.