Table 3.
Pooled results on the association between the VDR ApaI polymorphism and T2DM risk.
| Aa vs aa | AA vs aa | (Aa + AA) vs aa | AA vs (Aa + aa) | A vs a | |||||||
| Variable | n (Cases/Controls) | OR (95% CI) | Ph/I2(%) | OR (95% CI) | Ph/I2(%) | OR (95% CI) | Ph/I2(%) | OR (95% CI) | Ph/I2(%) | OR (95% CI) | Ph/I2(%) |
| Overall | 19 (2595/3557) | 0.97 (0.93, 1.01) | 0.522/0% | 0.96 (0.89, 1.03) | 0.209/20.1% | 0.98 (0.95, 1.01) | 0.408/3.9% | 1.03 (0.94, 1.13) | 0.259/16% | 0.99 (0.95, 1.03) | 0.285/13.8% |
| Ethnicity | |||||||||||
| Asian | 7 (680/702) | 1.03 (0.93, 1.15) | 0.482/0.0% | 0.95 (0.75, 1.21) | 0.178/32.8% | 1.01 (0.92, 1.10) | 0.216/27.8% | 0.92 (0.70, 1.20) | 0.547/0.0% | 0.99 (0.90, 1.09) | 0.145/37.1% |
| Caucasian | 10 (1701/2630) | 0.94 (0.89, 0.99) | 0.511/0.0% | 0.94 (0.86, 1.01) | 0.291/16.5% | 0.96 (0.93, 1.00) | 0.588/0.0% | 1.01 (0.91, 1.12) | 0.220/24.3% | 0.98 (0.93, 1.02) | 0.576/0.0% |
| Indian | 1 (89/100) | 1.04 (0.80, 1.35) | – | 1.13 (0.73, 1.75) | – | 1.04 (0.87, 1.25) | – | 1.12 (0.67, 1.88) | – | 1.06 (0.86, 1.32) | – |
| Mixed | 1 (125/125) | 0.99 (0.86, 1.14) | – | 1.17 (0.91, 1.50) | – | 1.02 (0.93, 1.12) | – | 1.52 (1.04, 2.22) | – | 1.13 (0.98, 1.30) | – |
| Geographic region | |||||||||||
| Asia | 13 (1489/1643) | – | 0.000/77.9% | 0.96 (0.86, 1.06) | 0.245/19.7% | 0.99 (0.95, 1.04) | 0.329/11.6% | 0.99 (0.87, 1.13) | 0.417/3.0% | 0.99 (0.94, 1.05) | 0.435/1.1% |
| Europe | 3 (638/4241) | 0.95 (0.86, 1.04) | 0.941/0% | 0.99 (0.84, 1.17) | 0.426/0.0% | 0.97 (0.91, 1.04) | 0.755/0.0% | 1.09 (0.88, 1.35) | 0.291/18.9% | 0.99 (0.94, 1.05) | 0.358/2.7% |
| South America | 1 (121/62) | 0.97 (0.63, 1.49) | – | 2.35 (0.53, 10.54) | – | 1.05 (0.71, 1.55) | – | 2.46 (0.54, 11.19) | – | 1.16 (0.76, 1.76) | – |
| North America | 2 (367/1428) | 0.90 (0.81, 1.00) | 0.135/55.3% | – | 0.038/76.7% | 0.96 (0.86, 1.08) | 0.061/71.5% | – | 0.023/80.6% | – | 0.017/82.5% |
| Sensitivity analysis | |||||||||||
| Overall | 10 (1222/1207) | 1.02 (0.95, 1.10) | 0.661/0.0% | 0.99 (0.88, 1.13) | 0.185/28.2% | 1.01 (0.96, 1.07) | 0.439/0.0% | 0.97 (0.83, 1.14) | 0.464/0.0% | 1.00 (0.94, 1.07) | 0.346/10.5% |
| Ethnicity | |||||||||||
| Asian | 4 (452/436) | 1.07 (0.94, 1.21) | 0.345/9.6% | 0.95 (0.58, 1.54) | 0.080/55.7% | 1.04 (0.94, 1.15) | 0.156/42.5% | 0.95 (0.69, 1.30) | 0.250/26.9% | 1.01 (0.85, 1.22) | 0.086/54.6% |
| Caucasian | 5 (681/671) | 0.99 (0.91, 1.08) | 0.616/0.0% | 0.97 (0.83, 1.13) | 0.237/27.7% | 0.99 (0.93, 1.06) | 0.557/0.0% | 0.96 (0.79, 1.16) | 0.362/7.8% | 0.98 (0.91, 1.06) | 0.592/0.0% |
| Indian | 1 (89/100) | 1.04 (0.80, 1.35) | – | 1.13 (0.73, 1.75) | – | 1.04 (0.87, 1.25) | – | 1.12 (0.67, 1.88) | – | 1.06 (0.86, 1.32) | – |
| Mixed | – | – | – | – | – | – | – | – | – | – | – |
| Geographic region | |||||||||||
| Asia | 8 (813/905) | 1.06 (0.97, 1.15) | 0.774/0.0% | 1.02 (0.88, 1.19) | 0.208/27.6% | 1.03 (0.97, 1.10) | 0.529/0.0% | 0.97 (0.80, 1.17) | 0.411/2.5% | 1.02 (0.95, 1.10) | 0.317/14.4% |
| Europe | 1 (308/240) | 0.94 (0.82, 1.07) | – | 0.89 (0.69, 1.13) | – | 0.95 (0.86, 1.05) | – | 0.92 (0.68, 1.24) | – | 0.94 (0.84, 1.06) | – |
| South America | 1 (101/62) | 0.97 (0.63, 1.49) | – | 2.35 (0.53, 10.54) | – | 1.05 (0.71, 1.55) | – | 2.46 (0.54, 11.19) | – | 1.16 (0.76, 1.76) | – |
CI = confidence interval, OR = odds ratio, T2DM = type 2 diabetes mellitus, VDR = vitamin D receptor.
The positive results of VDR polymorphisms and type 2 diabetes mellitus risk.