Table 4.
Pooled results on the association between the VDR TaqI polymorphism and T2DM risk.
| Tt vs tt | TT vs tt | (Tt + TT) vs tt | TT vs (Tt + tt) | T vs t | |||||||
| Variable | n (Cases/Controls) | OR (95% CI) | Ph/I2(%) | OR (95% CI) | Ph/I2(%) | OR (95% CI) | Ph/I2(%) | OR (95% CI) | Ph/I2(%) | OR (95% CI) | Ph/I2(%) |
| Overall | 24 (3221/4027) | 1.00 (0.94, 1.07) | 0.001/54.1% | 0.98 (0.93, 1.03) | 0.000/72.0% | 1.00 (0.97, 1.02) | 0.001/53.4% | 0.96 (0.88, 1.06) | 0.000/65.5% | 0.99 (0.95, 1.03) | 0.000/63.8% |
| Ethnicity | |||||||||||
| Asian | 5 (621/612) | – | 0.001/77.6% | 0.99 (0.97, 1.01) | 0.134/46.3% | – | 0.000/86.7% | 1.03 (0.98, 1.08) | 0.785/0.0% | 1.00 (0.97, 1.03) | 0.156/39.8% |
| Caucasian | 13 (2105/2870) | 1.03 (0.94, 1.13) | 0.000/65.8% | 0.93 (0.83, 1.05) | 0.000/68.2% | 1.00 (0.95, 1.06) | 0.000/65.7% | 0.88 (0.75, 1.05) | 0.000/69.2% | 0.97 (0.90, 1.04) | 0.000/68.9% |
| Indian | 5 (370/420) | 1.00 (0.87, 1.14) | 0.703/0.0% | 1.00 (0.75, 1.33) | 0.063/55.1% | 0.99 (0.91, 1.07) | 0.323/14.3% | 1.07 (0.65, 1.77) | 0.003/74.8% | 1.03 (0.83, 1.27) | 0.003/74.8% |
| Mixed | 1 (125/125) | 0.90 (0.76, 1.07) | – | 0.94 (0.71, 1.25) | – | 0.94 (0.84, 1.06) | – | 1.12 (0.76, 1.65) | – | 0.99 (0.84, 1.15) | – |
| Geographic region | |||||||||||
| Africa | 1 (50/50) | 1.05 (0.78, 1.40) | – | 0.95 (0.70, 1.29) | – | 1.00 (0.85, 1.17) | – | 0.83 (0.52, 1.31) | – | 0.94 (0.76, 1.16) | – |
| Asia | 16 (1983/1964) | 0.98 (0.87, 1.10) | 0.000/66.6% | – | 0.000/93.7% | 0.98 (0.94, 1.02) | 0.000/71.9% | – | 0.000/80.1% | – | 0.000/78.8% |
| Europe | 3 (638/423) | 1.02 (0.94, 1.11) | 0.869/0.0% | 1.06 (0.96, 1.17) | 0.704/0.0% | 1.02 (0.97, 1.07) | 0.786/0.0% | 1.10 (0.95, 1.29) | 0.678/0.0% | 1.05 (0.98, 1.12) | 0.627/0.0% |
| South America | 2 (183/162) | 1.09 (0.95, 1.26) | 0.619/0.0% | 1.11 (0.95, 1.29) | 0.597/0.0% | 1.05 (0.98, 1.14) | 0.992/0.0% | 1.06 (0.82, 1.35) | 0.203/38.3% | 1.06 (0.82, 1.35) | 0.343/0.0% |
| North America | 2 (367/1428) | 0.97 (0.89, 1.06) | 0.317/0.0% | 0.99 (0.88, 1.10) | 0.713/0.0% | 0.99 (0.93, 1.04) | 0.395/0.0% | 1.02 (0.87, 1.19) | 0.595/0.0% | 0.99 (0.93, 1.07) | 0.894/0.0% |
| Sensitivity analysis | |||||||||||
| Overall | 12 (1421/1420) | 0.94 (0.84, 1.05) | 0.001/64.4% | – | 0.000/81.5% | – | 0.000/83.8% | 1.00 (0.87, 1.15) | 0.000/71.3% | – | 0.000/81.6% |
| Ethnicity | |||||||||||
| Asian | 3 (489/429) | – | 0.000/91.9% | 1.00 (0.97, 1.02) | 0.095/64.1% | – | 0.000/94.6% | 1.02 (0.97, 1.08) | 0.741/0.0% | 1.00 (0.93, 1.07) | 0.034/70.4% |
| Caucasian | 5 (663/671) | – | 0.001/79.8% | – | 0.000/86.9% | – | 0.000/87.0% | – | 0.000/80.1% | – | 0.000/89.3% |
| Indian | 4 (269/320) | 1.01 (0.86, 1.18) | 0.560/0.0% | 1.09 (0.67, 1.77) | 0.051/61.3% | 1.00 (0.90, 1.11) | 0.267/24.1% | – | 0.002/79.6% | – | 0.003/78.6% |
| Mixed | – | – | – | – | – | – | – | – | – | – | – |
| Geographic region | |||||||||||
| Africa | – | – | – | – | – | – | – | – | – | – | – |
| Asia | 9 (930/1018) | 0.86 (0.72, 1.03) | 0.000/72.4% | – | 0.000/95.5% | – | 0.000/95.3% | – | 0.000/79.1% | – | 0.000/88.4% |
| Europe | 1 (308/240) | 1.04 (0.93, 1.16) | – | 1.10 (0.97, 1.24) | – | 1.04 (0.98, 1.10) | – | 1.10 (0.97, 1.24) | – | 1.08 (0.99, 1.18) | – |
| South America | 2 (183/162) | 1.09 (0.95, 1.26) | 0.619/0.0% | 1.11 (0.95, 1.29) | 0.597/0.0% | 1.05 (0.98, 1.14) | 0.992/0.0% | 1.06 (0.82, 1.35) | 0.203/38.3% | 1.06 (0.82, 1.35) | 0.343/0.0% |
CI = confidence interval, OR = odds ratio, T2DM = type 2 diabetes mellitus, VDR = vitamin D receptor.
The positive results of VDR polymorphisms and type 2 diabetes mellitus risk.