Table 5.
Credibility analysis of positive results in the present study.
| Credibility | |||||
| Prior probability of 0.001 | |||||
| Variables | Model | OR (95% CI) | I2 (%) | FPRP | BFDP |
| VDR BsmI polymorphism and T2DM risk | |||||
| Asian | BB vs (Bb + bb) | 0.77 (0.60, 0.99) | 40.5 | 0.979 | 0.998 |
| VDR FokI polymorphism and T2DM risk | |||||
| Overall | FF vs ff | 0.90 (0.84, 0.96) | 51.6 | 0.579 | 0.990 |
| (FF + Ff) vs ff | 0.98 (0.96, 1.00) | 45.4 | 0.980 | 1.000 | |
| FF vs (Ff + ff) | 0.83 (0.75, 0.92) | 62.4 | 0.280 | 0.954 | |
| F vs f | 0.93 (0.89, 0.97) | 67.6 | 0.422 | 0.989 | |
| Asian | FF vs ff | 0.87 (0.82, 0.93) | 34.2 | 0.041 | 0.797 |
| (FF + Ff) vs ff | 0.97 (0.94, 0.99) | 0.0 | 0.775 | 0.999 | |
| FF vs (Ff + ff) | 0.79 (0.69, 0.90) | 53.3 | 0.284 | 0.945 | |
| F vs f | 0.93 (0.90, 0.96) | 45.9 | 0.007 | 0.604 | |
| Indian | (FF + Ff) vs ff | 0.19 (0.07, 0.49) | – | 0.992 | 0.981 |
| F vs f | 0.28 (0.13, 0.62) | – | 0.991 | 0.985 | |
| Africa | FF vs ff | 0.77 (0.62, 0.96) | 54.9 | 0.957 | 0.997 |
| FF vs (Ff + ff) | 0.67 (0.56, 0.81) | 51.1 | 0.063 | 0.591 | |
| Asia | FF vs ff | 0.91 (0.84, 0.98) | 50.5 | 0.927 | 0.999 |
| (FF + Ff) vs ff | 0.97 (0.95, 1.00) | 37.5 | 0.980 | 1.000 | |
| FF vs (Ff + ff) | 0.84 (0.75, 0.95) | 56.9 | 0.846 | 0.995 | |
| F vs f | 0.94 (0.89, 0.99) | 60.7 | 0.951 | 0.999 | |
| Sensitivity analysis for VDR FokI polymorphism and T2DM risk | |||||
| Overall | FF vs ff | 0.93 (0.87, 1.00) | 15.9 | 0.980 | 1.000 |
| FF vs (Ff + ff) | 0.89 (0.81, 0.97) | 21.8 | 0.888 | 0.997 | |
| F vs f | 0.96 (0.92, 1.00) | 36.6 | 0.980 | 1.000 | |
| Asian | FF vs ff | 0.92 (0.83, 1.00) | 47.0 | 0.980 | 0.999 |
| Caucasian | FF vs (Ff + ff) | 0.85 (0.74, 0.98) | 3.6 | 0.962 | 0.998 |
| F vs f | 0.94 (0.88, 1.00) | 37.3 | 0.980 | 1.000 | |
| Mixed | Ff vs ff | 1.25 (1.05, 1.48) | – | 0.907 | 0.996 |
| (FF + Ff) vs ff | 1.15 (1.01, 1.31) | – | 0.973 | 0.999 | |
| Africa | FF vs ff | 0.85 (0.71, 1.00) | – | 0.980 | 0.999 |
| FF vs (Ff + ff) | 0.69 (0.53, 0.91) | – | 0.935 | 0.994 | |
| F vs f | 0.84 (0.74, 0.95) | – | 0.846 | 0.995 | |
| Asia | FF vs ff | 0.92 (0.84, 1.00) | 38 | 0.980 | 0.999 |
| F vs f | 0.96 (0.92, 1.00) | 32.7 | 0.980 | 1.000 | |
| VDR ApaI polymorphism and T2DM risk | |||||
| Caucasian | Aa vs aa | 0.94 (0.89, 0.99) | 0.0 | 0.951 | 0.999 |
| (Aa + AA) vs aa | 0.96 (0.93, 1.00) | 0.0 | 0.980 | 1.000 | |
| Mixed | AA vs (Aa + aa) | 1.52 (1.04, 2.22) | – | 0.985 | 0.997 |
| North America | Aa vs aa | 0.90 (0.81, 1.00) | 55.3 | 0.980 | 0.999 |
BFDP = Bayesian false discovery probability, CI = confidence interval, FPRP = false-positive report probabilities, OR = odds ratio, T2DM = type 2 diabetes mellitus, VDR = vitamin D receptor.
The positive results of VDR polymorphisms and type 2 diabetes mellitus risk.