Table 2.
Potential Low-Level Resistance | Low-Level Resistance | Intermediate Resistance | High-Level Resistance | ||||||
Drug Classification | Number of cases | Mutations | Number of cases | Mutations | Number of cases | Mutations | Number of cases | Mutations | |
Protease Inhibitors | atazanavir/r (ATV/r) | 2 | M46L|M46I | 1 | V82A | ||||
fosamprenavir/r (FPV/r) | 5 | L33F|V82A|M46L|M46I | |||||||
indinavir/r (IDV/r) | 2 | M46L|M46I | 1 | V82A | |||||
lopinavir/r (LPV/r) | 2 | M46L|M46I | 1 | V82A | |||||
saquinavir/r (SQV/r) | 2 | V82A|M46I | |||||||
nelfinavir (NFV) | 2 | V82A|M46L | 2 | V82A|M46I | |||||
tipranavir/r (TPV/r) | 2 | L33F|Q58E | |||||||
Nucleoside Reverse Transcriptase Inhibitors | lamivudine (3TC) | 1 | K65R | ||||||
abacavir (ABC) | 1 | K65R | |||||||
zidovudine (AZT) | 1 | K219Q | 1 | T215A | |||||
stavudine (D4T) | 2 | V75VI|K219Q | 1 | T215A | 1 | K65R | |||
didanosine (DDI) | 1 | V75VI | 1 | K65R | |||||
emtricitabine (FTC) | 1 | K65R | |||||||
tenofovir (TDF) | 1 | K65R | |||||||
Non-nucleoside Reverse Transcriptase Inhibitors | efavirenz (EFV) | 2 | V179D | 1 | A98G | 1 | Y181C+G190S | ||
etravirine (ETR) | 3 | A98G|V106I|V179D | 1 | Y181C+G190S | |||||
nevirapine (NVP) | 3 | V179E|V106I|V179D | 1 | A98G | 1 | Y181C+G190S | |||
rilpivirine (RPV) | 2 | V106I|V179D | 1 | A98G | 1 | Y181C+G190S |