Table 3.
Specific drug treatment program.
| Study | TAC regimens | CTX regimens |
| Wang[20] | Oral TAC 0.05 mg/kg/day for the 6 mo (target trough blood concentration of 3–5 ng/mL) | IV CTX once a mo for 6 mo (accumulated dosage of 7.5–11.5 g); oral prednisone 0.5 mg/kg/day for 2 mo with gradual tapering |
| Liang et al[21] | Oral TAC 0.05–0.1 mg/kg/day (target trough blood concentration of 5–10 ng/mL for 6 mo and then 4–6 ng/mL in the subsequent 3 mo with gradual tapering) | IV CTX 0.5–0.75 g/m2 once a month for 6 mo and then once in every 2–3 mo; oral prednisone 1 mg/kg/day for 1 mo with gradual tapering |
| Penget al[22] | Oral TAC 0.05–0.1 mg/kg/day (the trough blood concentration of 5–10 ng/mL for 18 mo) | IV CTX 0.8–1.0 g once a mo for 6 mo and then once in every 2–3 mo; oral prednisone 1 mg/kg/day for 2–3 mo with gradual tapering |
| Liang[23] | Oral TAC 0.05 mg/kg/day (the trough blood concentration of 4–10 ng/mL for 6 mo) | IV CTX 0.8–1.2 g once in every 2 wk for 2 mo and then once a mo; oral prednisone initial dose of 0.5 mg/kg/day |
| Chen et al,[24] | Oral TAC 0.05 mg/kg/day (the trough blood concentration of 3–8 ng/mL for 6 mo) | IV CTX 0.5–0.75 g/m2 once a mo for 6 months; oral prednisone 0.5 mg/kg/day for 2 mo with gradual tapering |
| Yao[25] | Oral TAC 0.05 mg/kg/day (the trough blood concentration of 4–10 ng/mL for 6 mo) | IV CTX 1 g once a mo for 6 mo; oral prednisone 0.8–1 mg/kg/day with gradual tapering |
| Liu[26] | Oral TAC 0.05 mg/kg/day (the trough blood concentration of 5–10 ng/mL for 6 mo) | IV CTX 0.6g once in every 2 wk for 3 mo and then 1g once a mo; oral prednisone oral prednisone 1 mg/kg/day for 2 mo with gradual tapering |
| Zhang[27] | Oral TAC 0.1 mg/kg/day (the trough blood concentration of 5–10 ng/mL for 6 mo) | IV CTX 0.75 g/m2 monthly and then once in every 2–3 mo (accumulated dosage was <10 g); oral prednisone 1 mg/kg/day for 2 mo with gradual tapering |
| Huet al[28] | Oral TAC 0.05 mg/kg/day (the trough blood concentration of 5–10 ng/mL for 6 mo then 4–6 ng/mL in case of remission) | Oral CTX 100 mg/day (accumulated dosage of 8–12 g); oral prednisone 0.5 mg/kg/day for 2 mo with gradual tapering |
CTX = cyclophosphamide, TAC = tacrolimus.