Figure 3. Response in Patient 002 Treated with G207.
In the top row, post-gadolinium sagittal T1-weighted images show the decreased size of the enhancing component of the tumor with interval development of numerous enlarging cystic spaces where G207 was inoculated. In the bottom row, sagittal fluid-attenuated inversion recovery (FLAIR) images show an interval decrease in the size of the FLAIR hyperintense component of the tumor in the frontal and temporal lobes after G207 treatment. These changes corresponded with an increase in the performance score from 80 before treatment to 100 by 12 months after treatment (on a scale from 0 to 100, with higher scores indicating better function). The patient had a continuous response 42 months after G207 treatment without any additional therapy