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. Author manuscript; available in PMC: 2021 Jul 16.
Published in final edited form as: Adv Exp Med Biol. 2019;1111:77–137. doi: 10.1007/5584_2018_288

Figure 2.

Figure 2.

Diverse domains within peripheral membrane protein exhibiting stereospecific PPIn-binding. Selected examples of unique PPIn-binding domains from the PX (a; p40phox PX domain in complex with PtdIns3P; PDB entry 1H6H), FYVE (b; EEA1-FYVE domain homodimer bound to Ins(1,3)P2; PDB entry 1JOC), C2 (c; PKCα-C2 domain in complex with Ca2+ and PtdIns(4,5)P2; PDB entry 3GPE), Tubby (d; C-terminal domain of Tubby bound to PtdIns(4,5)P2; PDB entry 1I7E), and PROPPINs (e; yeast PROPPIN Hsv2; PDB entry 4EXV) domain families that exhibit stereospecific coordination of the target PPIn lipid. In each of these structures, sequences features identified as defined membrane insertion elements are highlighted in red. For further details about each of these domains, please refer to Sections 5.3 (PX), 5.4 (FYVE), 5.5 (C2), 5.6 (Tubby), and 5.7 (PROPPINs) of the text. Prepared using the PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC.