Table 3.
Averaged diagnostic performance of B-mode ultrasound (US) and all possible combinations of multiparametric US with two, three, and four parameters.
| Sensitivity (%) | 95% CI | p-values | Specificity (%) | 95% CI | p-values | +LR | -LR | AUC | p-values | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 Parameter | B-mode | 90.8 (236/260) | 86.6 – 94.0 | 45.8 (108/236) | 39.3 – 52.3 | 1.67 | 0.2 | 0.683 | |||
| 2 Parameters | B-mode + VTIQ | 96.2 (250/260) | 93.0 – 98.1 | 0.0005 | 44.1 (104/236) | 37.6 – 50.7 | 0.1336 | 1.72 | 0.087 | 0.701 | 0.0241 |
| B-mode + Doppler | 96.5 (251/260) | 93.5 – 98.4 | 0.0035 | 39.8 (94/236) | 33.5 – 46.4 | 0.0824 | 1.6 | 0.087 | 0.682 | 0.9643 | |
| B-mode + CEUS | 96.5 (251/260) | 93.5 – 98.4 | 0.0003 | 29.7 (70/236) | 23.9 – 35.9 | < 0.0001 | 1.37 | 0.12 | 0.631 | 0.0002 | |
| 3 Parameters | B-mode + VTIQ + Doppler | 89.2 (232/260) | 84.8 – 92.7 | 0.5563 | 68.6 (162/236) | 62.3 – 74.5 | < 0.0001 | 2.85 | 0.16 | 0.789 | 0.0001 |
| B-mode + VTIQ + CEUS | 91.2 (237/260) | 87.0 – 94.3 | 1 | 71.2 (168/236) | 65.0 – 76.9 | < 0.0001 | 3.16 | 0.12 | 0.812 | 0.0001 | |
| B-mode + Doppler + CEUS | 93.5 (243/260) | 89.7 – 96.1 | 0.7103 | 52.1 (123/236) | 45.5 – 58.6 | 0.0872 | 1.95 | 0.13 | 0.728 | 0.0183 | |
| 4 Parameters | B-mode + VTIQ + Doppler + CEUS | 81.5 (212/260) | 76.3 – 86.1 | < 0.0001 | 62.3 (147/236) | 55.8 – 68.5 | < 0.0001 | 2.16 | 0.3 | 0.719 | 0.023 |
P-values refer to B-mode US. CI: confidence interval, LR: likelihood ratio, AUC: area under the curve, VTIQ: virtual touch IQ elastography, CEUS: contrast-enhanced US.