TABLE 2.

Differences in brain function and structure in patients with ETv and DTv compared with healthy control subjects

Anatomical Reference	Cluster Size (mm3)		Cluster Peak t Value	Cluster Peak x, y, z
Common Abnormalities
Functional activity during speech production
Patients > controls
L. primary somatosensory cortex	ETv	86	3.1	−19, −36, 55
	DTv	556	3.8	−12, −39, 55
Patients < controls
L. inferior parietal lobule	ETv	599	−3.48	−47, −53, 27
	DTv	471	−3.3	−47, −50, 20
Cortical thickness
Patients > controls
L. superior parietal lobule extending to primary somatosensory and primary motor cortex	ETv	1373	5.9	−16, −47, 66
	DTv	1535	4.7	−13, −49, 65
R. superior parietal lobule extending to primary somatosensory cortex	ETv	1094	5.2	22, −42, 69
	DTv	1011	4.6	17, −44, 68
L. inferior temporal gyrus	ETv	595	4.5	−29, −13, −63
	DTv	16	3	−30, −16, −61
Gray matter volume
Patients > control
R. inferior temporal gyrus	ETv	801	4.5	58, −24, −27
	DTv	2291	6.3	58, −26, −26
Distinct Abnormalities
Functional activity during speech production
ETv > DTv patients
R. cerebellum (lobule VIII)		343	−4.8	37, −43, −43
DTv > ETv patients
R. insula		343	3.3	37, −12, 17
R. superior temporal gyrus		300	3.1	61, −29, −13
Cortical thickness
ETv > DTv patients
R. inferior temporal gyrus		596	4.7	46, −28, −25
DTv > ETv patients
L. primary motor cortex		156	3.9	−41, −12, 42
ET voice + hand > ET voice
L. inferior parietal lobule		193	−5.6	−57, −26, 24
L. superior parietal lobule		207	−4.2	−11, −41, 41
R. superior temporal gyrus		170	−4.9	59, −7, −3
Gray matter volume
DTv > ETv patients
L. premotor cortex extending to bilateral supplementary motor area		3460	4.1	−24, −14, 64

Abbreviations: L., left; ETv, essential voice tremor; DTv, dystonic tremor of voice; R., right; ET, essential tremor.