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Binding of compound I with HSP27. (A) Multimer HSP27 protein crystal in the ribbon structure (6DV5.pdb). (B) Binding pocket between two monomers with compounds shown in space fill; (C) compound I binding to the HSP27 phosphorylation site, showing that SER78 is blocked from phosphorylation; and (D) 2D ligand interaction diagram of compound I docked to the HSP27 pocket.
