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. Author manuscript; available in PMC: 2021 Jul 16.
Published in final edited form as: J Med Chem. 2021 Feb 1;64(3):1570–1583. doi: 10.1021/acs.jmedchem.0c01537

Figure 7.

Figure 7.

Downregulation of ARs by compound I through the proteasome pathway. AR or mutated AR (AR-V7) expression was analyzed by western blotting after treatment by compound I with MG132 or without it. The experiment was repeated three times independently, and the representative image and quantification are shown. Data are expressed as mean ± SD (n = 3). **p < 0.01 compared to DMSO treatment by the unpaired t-test. #p < 0.05, ##p < 0.01 combination compared to only compound I treatment by the unpaired t-test.