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. Author manuscript; available in PMC: 2022 Jun 2.
Published in final edited form as: J Am Chem Soc. 2021 May 20;143(21):8099–8107. doi: 10.1021/jacs.1c02453

Scheme 4.

Scheme 4.

Synthesis of a First-Generation Inhibitor Librarya

aKey: (a) H2, Pd/C; (b) TFAA; (c) (i) S-Ethyl tetrazole, 4; (ii) t-BuOOH; (d) NH4OH; (e) RxCO2H (X = 1−325), HBTU, HOBt; (f) NBS.