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. 2020 Oct 21;9(1):2303–2314. doi: 10.1080/22221751.2020.1830717

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — The increased BCR repertoire diversity in HFRS cases. (A) BCR diversity, assessed by chaoE and chao1, was rapidly expanded in cases with antibody titres producing fourfold increase in either IgM or IgG subtype. Ac represents the acute phase and Re represents the recovery phase before and after fourfold rises in antibody titres. (B) V and J gene rearrangement characteristics from two typical cases, moderate P9 and severe P18, were depicted based on the read number of genes. The top 15V genes and all of the J genes were labelled in the circos plots. Genes from the same major class were assigned the same color. For example, IGHV4-34 and IGHV4-39 are shown in pink, and IGHV2-5 and IGHV2-70 are shown in orange. (C) IGHV segment usage ratio in HTNV patients. Packaged bars indicate the respective percentages of top 20 V genotypes. (D) Dominant antibody sequence characteristics identified following a fourfold rise in titre. The proportion of IGHV1-18 and IGHV 5-51 were calculated for the total and corresponding IGHV genotype. The region of V_H, D_H, and J_H was confirmed by IgBlast in NCBI.