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. Author manuscript; available in PMC: 2021 Jul 16.
Published in final edited form as: Brain Res Bull. 2019 Jun 5;150:216–230. doi: 10.1016/j.brainresbull.2019.05.024

Fig. 4.

Fig. 4.

A schematic of polyplex formation and cellular uptake. Genetic material carries a negative charge due to the phosphate groups it contains. The negatively charged genetic material can be complexed with polycationic biomaterials to form a polyplex, which carries an overall positive charge. Mammalian cells carry a net negative charge due to the presence of surface proteoglycans. The positively charged polyplex is attracted to the negatively charged cell surface. The polyplex interacts with the cell surface and induces cellular uptake of the polyplex via endocytosis.