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. Author manuscript; available in PMC: 2021 Jul 16.
Published in final edited form as: Brain Res Bull. 2019 Jun 5;150:216–230. doi: 10.1016/j.brainresbull.2019.05.024

Table 1.

The Advantages and Disadvantages of Viral and Biomaterial Vectors for Gene Delivery.

Vector Type Advantages Disadvantages
Viral High transduction efficiency Immunogenicity
Limited packaging capacity
Expensive to manufacture
Difficult to fabricate
Low production yields
Single administration
Biomaterial Low production cost Cytotoxicity
Ease of production Low transfection efficiency
High production yields
High tunability
Repeat administration capability